KK-LC-1 may be an effective prognostic biomarker for gastric cancer

Abstract Background The objective of the study was to detect expression Kita-Kyushu lung cancer antigen-1 (KK-LC-1) in gastric (GC) specimens and analyse associations between KK-LC-1 clinicopathological parameters clinical prognosis. Methods All 94 patients this were GC who underwent surgical resection. protein tissue detected by immunohistochemistry. This report applies histological score (H-score) evaluate expression. To calculate indicator, number positive cells each section their staining intensity converted corresponding values. cytoplasm normal tissues scored obtain respective H chi-square test, Kaplan-Meier method Cox regression used linear association data Results In cytoplasm, tumour significantly higher than that ( P < 0.001). Using median H-score as cut-off value, we discovered with high levels had favourable overall survival (OS) = 0.016), result statistically significant analysis. Additionally, a negative correlation found pathological grade 0.036), more observed intestinal type diffuse 0.008). Conclusions Our research showed greater tissues, associated longer OS patients. can be biomarker for good prognosis